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Updated: May 11, 2025
Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
The Association Between Helicobacter pylori Infection and Eosinophilic Esophagitis: Systematic Review and
Lucía Gutiérrez-Ramírez1,2, Sandra L Garcia-Dionisio1,3, Sara Feo-Ortega4
1Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.
Background:
Exposure to Helicobacter pylori (H. pylori) has been associated with reduced odds of eosinophilic esophagitis (EoE).
Aims:
To conduct a systematic review and meta-analysis of epidemiological studies in order to quantify the association between H. pylori infection and EoE, and to assess the certainty of the evidence linking both conditions.
Methods:
A comprehensive literature search was conducted in MEDLINE/PUBMED, EMBASE, and SCOPUS databases (up to September 2024) to identify observational epidemiological studies that assessed the association between objectively measured H. pylori infection and EoE. The risk of study bias was assessed structurally using the ROBINS-E tool. Data were pooled using a random-effects meta-analysis. The certainty of the evidence was assessed using the GRADE approach.
Results:
Sixteen studies comprising 30,650 patients and 291,908 controls were included. Exposure to H. pylori was associated with a significant reduction in the odds of EoE (pooled odds ratio [OR] 0.56; 95% CI, 0.46-0.70; I2 50%) [low-certainty evidence]. The protective effect of H. pylori was stronger in case-control studies (OR 0.49; 95% CI, 0.35-0.69) than in cohort studies (OR 0.76; 95% CI, 0.58-0.98) and was statistically significant in retrospective studies (OR 0.57; 95% CI, 0.45-0.72) and studies with high or very high risk of bias (OR 0.52; 95% CI, 0.42-0.64), but not in prospective studies (OR 0.56; 95% CI, 0.27-1.18) or those with moderate to low risk of bias (OR, 0.91; 95% CI, 0.69-1.21).
Conclusions:
The association between H. pylori and EoE is mainly supported by retrospective studies with a high risk of bias. Further well-designed studies are needed.
Trial Registration:
PROSPERO number: CRD42024586653.
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