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Folate from probiotic bacteria and its therapeutic applications.

G Megala1, M Kavitha2

  • 1School of BioSciences and Technology, Vellore Institute of Technology, Vellore, 632014, Tamil Nadu, India.

Archives of Microbiology
|April 18, 2025
PubMed
Summary

Probiotic bacteria can naturally produce folate (vitamin B9), offering a safer alternative to synthetic folic acid. These beneficial microbes enhance gut health and show potential therapeutic applications in various diseases.

Keywords:
FolateOne carbon metabolismProbioticsTherapeutic applications

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Area of Science:

  • Nutritional Biochemistry
  • Microbiology
  • Gastroenterology

Background:

  • Folate (vitamin B9) is essential for DNA synthesis and repair, but the human body cannot produce it.
  • Dietary sources and microbial synthesis are the primary ways to obtain folate.
  • Certain probiotic strains, including Lactiplantibacillus, Lactococcus, Bifidobacterium, and Streptococcus, are capable of producing folate.

Purpose of the Study:

  • To review folate metabolism, its health significance, and deficiency issues.
  • To explore folate synthesis by probiotic bacterial strains.
  • To discuss the toxicological impacts and therapeutic potential of microbial folates.

Main Methods:

  • Literature review focusing on folate metabolism, synthesis, and health implications.
  • Analysis of studies on folate-producing probiotic strains.
  • Examination of toxicological data and therapeutic applications.

Main Results:

  • Probiotic-derived folates offer advantages over synthetic folic acid due to better absorption and fewer side effects.
  • Folate-producing probiotics contribute to improved gut microbiota and overall well-being.
  • These probiotics demonstrate potential therapeutic benefits for autoimmune, metabolic, and cardiovascular diseases, wound healing, drug delivery, and cancer.

Conclusions:

  • Microbial folate synthesis by probiotics presents a promising and safer alternative to conventional folic acid supplementation.
  • Folate-producing probiotics have significant potential for improving human health and treating various medical conditions.