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Related Experiment Video

Updated: May 11, 2025

Multispectral Optoacoustic Tomography for Functional Imaging in Vascular Research
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Photoacoustic-Strain (PAS) Imaging for Tissue Microcirculation Assessment.

Xinyue Huang, David Qin, Samuel Morais

    IEEE Transactions on Medical Imaging
    |April 18, 2025
    PubMed
    Summary

    Photoacoustic-strain (PAS) imaging is a new non-invasive technique to assess tissue microcirculation. This method monitors blood flow changes under pressure, offering insights into vascular health and disease.

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    Area of Science:

    • Biomedical Engineering
    • Medical Imaging
    • Physiology

    Background:

    • Microcirculation is vital for tissue health, facilitating nutrient and gas exchange.
    • Dysfunction in microcirculation is linked to various systemic diseases.
    • Current methods for assessing microcirculation can be invasive or lack spatial resolution.

    Purpose of the Study:

    • To introduce and validate photoacoustic-strain (PAS) imaging as a novel non-invasive method for assessing tissue microcirculation.
    • To demonstrate the capability of PAS imaging in real-time monitoring of blood volume changes and microcirculatory dynamics.
    • To establish PAS imaging as a robust tool for detecting microcirculatory alterations.

    Main Methods:

    • Development of photoacoustic-strain (PAS) imaging by combining ultrasound/photoacoustic imaging with external tissue deformation.
    • Real-time monitoring of blood volume changes during applied pressure and subsequent release.
    • Post-processing algorithms to reconstruct spatially resolved maps of blood displacement and reperfusion rates.
    • In silico and in vivo validation of PAS imaging performance.

    Main Results:

    • PAS imaging successfully monitored blood displacement and refilling dynamics in microcirculation.
    • Reconstructed maps provided insights into microcirculatory flow and reperfusion rates.
    • The technique demonstrated high sensitivity and robustness in detecting microcirculatory changes.
    • PAS imaging differentiated microcirculatory status under conditions like vascular occlusion and varying tissue temperatures.

    Conclusions:

    • Photoacoustic-strain (PAS) imaging is a validated, non-invasive tool for evaluating tissue microcirculation.
    • PAS imaging offers real-time insights into microcirculatory function and dynamics.
    • This technology holds significant potential for understanding and diagnosing diseases related to microcirculatory impairment.