Related Experiment Video
Updated: Dec 22, 2025

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
Published on: February 5, 2019
Cytoprotective Nanoencapsulation of Probiotic Cells within Fe3+-Phytic Acid Nanoshells
Sang Yeong Han1, Nayoung Kim1, Duc Tai Nguyen1
1Department of Chemistry, KAIST, Daejeon 34141, Korea.
Abstract:
Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents the construction of durable nanoshells composed of an Fe3+-phytic acid metal-organic complex around individual probiotic cells, providing exceptional cytoprotective properties, in single-cell nanoencapsulation. Nanoencapsulated Levilactobacillus brevis maintains high viability under simulated gastric fluid and the antibiotic tetracycline. The Fe3+-phytic acid nanoshells provide an effective platform for improving the viability and functionality of probiotics in therapeutic and nutritional applications.

