Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

RetroMPA: A Molecular Property-Aware Auxiliary Framework for Enhancing Retrosynthesis Prediction.

Journal of chemical information and modeling·2026

Same author

Declining age-adjusted mortality but persistent inequalities in chronic obstructive pulmonary disease in the United States, 1999-2024: a CDC WONDER analysis contextualized by GBD 2023.

Frontiers in public health·2026

Same author

Real-time patient-specific microwave ablation zone prediction via a unified bioheat solver and MRI-informed perturbation learning.

Medical image analysis·2026

Same author

Safety, efficacy, and pharmacokinetics of eratrectinib (VC004) in solid tumors with NTRK fusions: phase 1 results from a phase 1/2 study.

Experimental hematology & oncology·2026

Same author

Tislelizumab combined with gemcitabine as first-line treatment in cisplatin-ineligible patients with locally advanced or metastatic urothelial carcinoma: a single center, single-arm phase 2 trial.

Frontiers in immunology·2026

Same author

Bioenergetic failure in diabetic peripheral neuropathy: from glucotoxicity to multidimensional metabolic imbalance.

Journal of neurology·2026

Search research articles

Related Experiment Video

Updated: May 11, 2025

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Published on: September 8, 2017

Dual AIE and Visible-Light-Driven Photoswitchable Polymer for Super-resolution Imaging.

Hongbo Yu¹, Ruiyao Li¹, Mei Wu²

¹The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Frontiers Science Center of Biomimetic Catalysis, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China.

ACS Applied Materials & Interfaces

|April 18, 2025

Summary

Researchers developed a novel polymer combining photochromic and aggregation-induced emission (AIE) properties. This new material enhances super-resolution imaging of polymer micelles with visible light, offering improved performance.

Keywords:

aggregation-induced emission diarylethene photoresponsive polymer super-resolution imaging tetraphenylethylene

More Related Videos

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

Published on: November 14, 2015

Super-resolution Imaging of the Bacterial Division Machinery

Super-resolution Imaging of the Bacterial Division Machinery

Published on: January 21, 2013

Related Experiment Videos

Last Updated: May 11, 2025

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Demonstration of a Hyperlens-integrated Microscope and Super-resolution Imaging

Published on: September 8, 2017

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

A 'Plug and Play' Method to Create Water-dispersible Nanoassemblies Containing an Amphiphilic Polymer, Organic Dyes and Upconverting Nanoparticles

Published on: November 14, 2015

Super-resolution Imaging of the Bacterial Division Machinery

Super-resolution Imaging of the Bacterial Division Machinery

Published on: January 21, 2013

Area of Science:

Polymer Chemistry
Materials Science
Nanotechnology

Background:

Photochromic polymers and aggregation-induced emission (AIE) materials offer unique optical properties.
Synergistic integration of these properties in polymers is underexplored.
AIE materials are crucial for advanced imaging techniques.

Purpose of the Study:

To synthesize a novel polymer integrating both photochromic (diarylethene, DAE) and AIE (tetraphenylethylene, TPE) characteristics.
To investigate the polymer's potential as a super-resolution probe.
To explore its application in imaging self-assembled polymer micelles.

Main Methods:

Synthesis of a TPE-DAE copolymer.
Characterization of photochromic, AIE, and fluorescence properties.
Application as a probe in super-resolution imaging of polystyrene-block-poly(ethylene oxide) (PSt-b-PEO) micelles.

Main Results:

Successful synthesis of the TPE-DAE polymer with combined AIE and photochromic functionalities.
Demonstrated high fluorescence ON/OFF ratios and visible-light-driven photocycloreversion.
Achieved super-resolution imaging of cylindrical micelles with high resolution and quantum yield.

Conclusions:

The novel TPE-DAE polymer exhibits synergistic photochromic and AIE properties.
It serves as an effective super-resolution probe for nanostructure imaging.
This material offers advantages over existing probes, including visible-light operation and enhanced performance.