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Haemostatic parameters in Cushing's syndrome.
Acta Medica Scandinavica
|January 1, 1985
Summary
Cushing's syndrome affects blood clotting, causing prolonged bleeding times and abnormal platelet aggregation. Treatment improved bleeding, while Factor VIII levels remained elevated, correlating with disease severity.
Area of Science:
- Hematology
- Endocrinology
Background:
- Cushing's syndrome is associated with various metabolic disturbances.
- The impact on hemostatic parameters requires further elucidation.
Purpose of the Study:
- To investigate hemostatic parameters in patients with Cushing's syndrome.
- To assess the effect of surgical treatment on bleeding times.
Main Methods:
- Evaluated bleeding times in 12 Cushing's syndrome patients.
- Assessed platelet aggregation (ADP, adrenaline, collagen).
- Measured thromboxane B2 production and Factor VIII activities (VIII:C, RAg, Rcof).
Main Results:
- Prolonged bleeding times were observed in some patients.
- Platelet aggregation was impaired in several patients.
- Factor VIII activities were elevated, particularly in severe cases, and correlated with disease severity.
Conclusions:
- Cushing's syndrome is linked to primary hemostasis defects and elevated Factor VIII.
- Surgical treatment can improve bleeding times.
- Hemostatic abnormalities correlate with clinical disease severity.