The relationship between primary hyperparathyroidism and frontal QRS-T angle

Area of Science:

• Cardiology
• Endocrinology
• Medical Diagnostics

Background:

• Primary hyperparathyroidism (PHPT) involves elevated parathyroid hormone (PTH) and hypercalcemia.
• Calcium homeostasis is vital for cardiac electrophysiology, influencing depolarization and repolarization.
• The frontal QRS-T angle, an electrocardiogram (ECG) measurement, reflects cardiac electrical activity.

Purpose of the Study:

• To investigate the relationship between the frontal QRS-T angle and newly diagnosed PHPT.
• To determine if PHPT patients exhibit altered frontal QRS-T angles compared to healthy controls.

Main Methods:

• A prospective cross-sectional study design was employed.
• 142 participants were included: 71 newly diagnosed PHPT patients and 71 healthy controls.
• Exclusion criteria included age under 18, chronic kidney disease, heart failure, pericardial effusion, or malignancy.

Main Results:

• PHPT patients had significantly higher systolic (132 mmHg) and diastolic (77.8 mmHg) blood pressure than controls (p < 0.001).
• The mean frontal QRS-T angle was -9.0° in PHPT patients and 2.0° in controls.
• A statistically significant difference (p < 0.001) was observed, with PHPT patients exhibiting wider QRS-T angles.

Conclusions:

• The frontal QRS-T angle is significantly different in newly diagnosed PHPT patients compared to healthy individuals.
• An increased frontal QRS-T angle in PHPT patients may serve as an early indicator of cardiovascular complication risk.
• ECG-derived frontal QRS-T angle could be a valuable parameter for risk stratification in PHPT management.