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Published on: May 18, 2022
From geroscience to precision geromedicine: Understanding and managing aging
Guido Kroemer1, Andrea B Maier2, Ana Maria Cuervo3
1Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Inserm U1138, Université Paris Cité, Sorbonne Université, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Institut, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Geroscience identifies aging mechanisms, viewing aging as influenced by gerogenes and gerosuppressors. This research targets precision geromedicine for tailored treatments based on individual aging biomarkers.
Area of Science:
- Gerontology and Molecular Biology
- Geroscience and Aging Mechanisms
Background:
- Significant advancements in understanding aging at molecular, cellular, and supracellular levels.
- Emergence of geroscience focused on identifying actionable hallmarks of aging.
Purpose of the Study:
- To define aging as a process influenced by gerogenes (promoting aging) and gerosuppressors (slowing aging).
- To explore gerogenes and gerosuppressors as targets for modeling and treating age-related diseases.
Main Methods:
- Utilizing new molecular profiling technologies to characterize gerogenic and gerosuppressive pathways.
- Analyzing interactions between genetic, environmental, behavioral, and psychological factors in aging.
Main Results:
- Identification of gerogenes and gerosuppressors associated with age-related diseases.
- Characterization of these pathways as biomarkers of aging.
- Establishing the foundation for precision geromedicine.
Conclusions:
- Geroscience offers a framework for understanding and intervening in the aging process.
- Precision geromedicine aims to tailor gerotherapeutics based on comprehensive individual profiles.
- Future clinical trials and regulatory approval are anticipated for personalized aging interventions.
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