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Updated: May 17, 2025

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Safeguarding genomic imprints in naive human pluripotency

Alejandro De Los Angeles1

  • 1Harvard Medical School, Boston, Massachusetts, USA; Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Stem Cell Reports
|April 18, 2025
PubMed
Summary

Naive human pluripotent stem cells (hPSCs) require specific conditions to maintain genomic imprinting. Partial MEK/ERK inhibition combined with ZFP57 overexpression stabilizes these essential imprints for reliable models.

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