Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

1.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.8K
Arteries and Arterioles01:16

Arteries and Arterioles

2.5K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
2.5K
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

2.0K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
2.0K
Vascular Resistance01:20

Vascular Resistance

3.0K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
3.0K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

2.3K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemerin knockout reveals sex difference in the role of chemerin in blood pressure and vascular remodeling.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Presence and Variability of the Microbiome in Perivascular Adipose Tissue: A Whole-Genome Sequencing Study in Dahl SS Rats.

Life (Basel, Switzerland)·2026
Same author

Surgical Induction of Mid-Thoracic Aortic Coarctation in Mice: A Reproducible Preclinical Model of Pressure-Induced Vascular Remodeling.

Current protocols·2026
Same author

5-Hydroxytryptamine may be a viable treatment option for hypertension resistant to diuretic treatment.

American journal of physiology. Heart and circulatory physiology·2025
Same author

Perivascular Adipocytes' Adipogenesis Is Defined by Their Anatomical Location in the Descending Thoracic Aorta.

Cells·2025
Same author

Single-nucleus analysis of thoracic perivascular adipose tissue reveals critical changes in cell composition, communication, and gene regulatory networks induced by a high fat hypertensive diet.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 12, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K

PVAT adipocyte: energizing, modulating, and structuring vascular function during normotensive and hypertensive

C Javier Rendon1, Stephanie W Watts2, G Andres Contreras1

  • 1Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, Michigan, United States.

American Journal of Physiology. Heart and Circulatory Physiology
|April 18, 2025
PubMed
Summary

Hypertension causes vascular remodeling, affecting perivascular adipose tissue (PVAT). Understanding PVAT

Keywords:
adipocytecardiovascular diseasehypertensioninflammationperivascular adipose tissue

More Related Videos

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
06:56

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

2.0K
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
07:24

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

7.4K

Related Experiment Videos

Last Updated: May 12, 2025

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

9.7K
Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
06:56

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

2.0K
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
07:24

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

7.4K

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Vascular Biology

Background:

  • Hypertension is a prevalent cardiovascular disease.
  • It involves significant vascular remodeling, including perivascular adipose tissue (PVAT).
  • PVAT plays a critical role in blood pressure regulation.

Purpose of the Study:

  • To review mechanisms of PVAT in blood pressure modulation.
  • To examine how hypertension influences these PVAT mechanisms.
  • To elucidate the interplay between hypertension and PVAT biology.

Main Methods:

  • Literature review of PVAT's role in hypertension.
  • Analysis of PVAT's bioactive factor secretion.
  • Examination of PVAT's mechanical and adipose-specific functions.

Main Results:

  • PVAT modulates blood pressure via soluble factors, mechanical support, and adipose functions.
  • Hypertension significantly impacts these PVAT regulatory mechanisms.
  • Remodeling of PVAT is a key feature in hypertensive vascular disease.

Conclusions:

  • PVAT is integral to blood pressure homeostasis.
  • Hypertension-induced changes in PVAT contribute to disease pathophysiology.
  • Further research into PVAT is crucial for understanding and treating hypertension.