Advanced Imaging in the Diagnosis of Cardiac Sarcoid and LV Noncompaction

Jade Tso1, Carly A Robinson1, Ahmadreza Ghasemiesfe2

  • 1University of California-Davis, School of Medicine, Sacramento, California, USA.

JACC. Case Reports
|April 18, 2025
PubMed

Insights

Diagnosing rare heart conditions like left ventricular noncompaction (LVNC) and cardiac sarcoidosis (CS) can be challenging. Advanced imaging techniques like PET and MRI are crucial for identifying their combined impact on heart failure.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Rare Diseases

Background:

  • Heart failure presents complex diagnostic challenges.
  • Co-occurrence of rare cardiac conditions like left ventricular noncompaction (LVNC) and cardiac sarcoidosis (CS) is infrequently encountered.
  • Accurate diagnosis is essential for effective patient management.

Purpose of the Study:

  • To illustrate the diagnostic utility of advanced imaging in a patient with coexisting LVNC and CS.
  • To highlight the contribution of each condition to the patient's heart failure.
  • To emphasize the importance of integrated diagnostic approaches for rare cardiovascular diseases.

Main Methods:

  • Case report of a 60-year-old male with heart failure.
  • Utilized Fluorodeoxyglucose positron emission tomography (FDG-PET) for metabolic assessment.
  • Employed cardiac magnetic resonance (CMR) for detailed cardiac structure and function evaluation.

Main Results:

  • FDG-PET identified active inflammation consistent with cardiac sarcoidosis.
  • CMR revealed characteristic features of left ventricular noncompaction.
  • Imaging data elucidated the distinct and combined roles of LVNC and CS in the patient's heart failure.

Conclusions:

  • Advanced imaging modalities (FDG-PET and CMR) are vital for diagnosing rare coexisting cardiac conditions.
  • This case underscores the necessity of comprehensive imaging in complex heart failure etiologies.
  • Accurate differentiation of contributing factors is key to optimizing treatment strategies for heart failure.

Related Concept Videos

Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
106
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
262
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
200