Meta-analysis of the efficacy of applying reduced surgery for the treatment of asymptomatic unresectable advanced gastric cancer
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View abstract on PubMed
Summary
This summary is machine-generated.For asymptomatic unresectable advanced gastric cancer, reduced surgery does not improve survival rates. This approach also increases complication risks compared to non-surgical treatment.
Area Of Science
- Oncology
- Surgical Oncology
- Gastroenterology
Background
- Advanced gastric cancer presents significant treatment challenges, particularly when unresectable.
- Asymptomatic patients with unresectable advanced gastric cancer require careful consideration of palliative treatment options.
Purpose Of The Study
- To systematically evaluate the efficacy and safety of reduction surgery in asymptomatic patients with unresectable advanced gastric cancer.
- To compare survival outcomes and complication rates between reduced surgery and non-surgical treatment.
Main Methods
- A meta-analysis was conducted using studies from PubMed, EMBASE, Cochrane Library, and Web of Science.
- Included studies were assessed for quality and bias using the Cochrane Risk of Bias Assessment Tool and Newcastle-Ottawa Scale.
- Data from 1 randomized controlled trial and 4 retrospective studies (1717 patients) were analyzed.
Main Results
- Reduced surgery did not demonstrate a survival benefit (1-, 3-, or 5-year survival rates) compared to non-surgical treatment.
- The reduced surgery group experienced a longer median survival time (11.58 months) but had higher incidence and morbidity rates (5.5% and 6.5% higher).
- Perioperative complications and mortality in the reduced surgery group were 15% and 4%, respectively.
Conclusions
- Current evidence indicates that reduced surgery for asymptomatic unresectable advanced gastric cancer does not offer long-term survival advantages.
- The procedure is associated with increased risks of complications and mortality.
- Further high-quality randomized controlled trials are needed to solidify these findings and guide clinical practice.
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