Related Experiment Video
Updated: May 11, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
Published on: March 23, 2022
Highlights of 2024: The multifaceted roles of ILC3s in mucosal immunity and inflammation
Xin Shen1,2, Xianzhi Gao3,4, Lie Wang3,4
1Co-Facility Center, Zhejiang University School of Medicine, Hangzhou, China.
Abstract:
In this article for the Highlights of 2024 Series, we discuss research on Group 3 innate lymphoid cells (ILC3s), which revealed their complex roles in mucosal immunity and inflammation. ILC3s can migrate from the gut to the kidneys, contributing to renal fibrosis. Their functions are metabolically regulated, with proteins such as nucleophosmin 1 and Tox2 influencing oxidative phosphorylation and glycolysis, respectively. ILC3s also express immune checkpoint molecules (e.g. cytotoxic T-lymphocyte antigen 4 and programmed cell death1), which modulate inflammation. These findings highlight the tissue-specific roles of ILC3s and the need for targeted immunotherapies.
Related Concept Videos
Renewal of Intestinal Stem Cells
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Inflammation
Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...

