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Published on: February 9, 2014
METTL3-mediated m6A modification in sepsis: current evidence and future perspectives
Zijun Wu1,2,3, Changhong Miao1,2,3, Hao Zhang1,2,3
1Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
None:
Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis and treatment have advanced in recent years, a specific therapy remains unavailable. Recently, significant progress has been made in studying the epigenetic RNA modification N6-methyladenosine (m6A) and its core methyltransferase METTL3. The role of m6A in sepsis has also been increasingly elucidated. This review aims to explore the pathological mechanisms of sepsis and its relationship with m6A, focusing on the role of the key m6A writer, METTL3, in sepsis.
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