Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Bulimia Nervosa01:30

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
Binge Eating Disorders01:23

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative analysis of bias and quality in YouTube videos on bariatric surgery and weight-loss medications.

Surgical endoscopy·2026
Same author

Managing Bariatric Surgical Emergencies: Evidence-Based Approaches for General Surgical Practice.

The American surgeon·2026
Same author

Assessing Socioeconomic Disparities in Outcomes: A Retrospective Analysis of Hartmann's Procedure vs PADLI Using the National Inpatient Sample.

The American surgeon·2025
Same author

The impact of the COVID-19 pandemic on emergency general surgery outcomes: a retrospective analysis of seven procedures.

Updates in surgery·2025
Same author

Resident Endoscopy Experience Correlates Poorly with Performance on a Virtual Reality Simulator.

Surgery journal (New York, N.Y.)·2022
Same author

Surgical Skills Olympiad: A 4-Year Experience in a General Surgery Residency Program.

Surgery journal (New York, N.Y.)·2021

Related Experiment Video

Updated: Jun 30, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

Weight Recidivism After Bariatric Surgery: A Narrative Review.

Qilin Cao1, Hooria Kazi1, Aram E Jawed2

  • 1Hackensack Meridian School of Medicine, Nutley, NJ, USA.

The American Surgeon
|April 19, 2025
PubMed
Summary

Weight regain after bariatric surgery affects 20-30% of patients. This review details hormonal, metabolic, and surgical factors contributing to weight regain (WR) and outlines management strategies including lifestyle changes, medications, and revisional surgery.

Keywords:
bariatric surgeryminimally invasive surgeryrevisional bariatric surgeryweight lossweight regain

More Related Videos

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Related Experiment Videos

Last Updated: Jun 30, 2026

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
11:58

A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers

Published on: August 21, 2021

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

  • Bariatric Surgery
  • Obesity Medicine
  • Metabolic and Endocrine Disorders

Background:

  • Bariatric surgery is effective for severe obesity but frequently complicated by postoperative weight regain (WR), impacting 20-30% of patients.
  • Weight regain is multifactorial, involving hormonal shifts like ghrelin rebound and leptin resistance, alongside metabolic adaptation leading to decreased energy expenditure.
  • Surgical factors, including suboptimal techniques, fistulas, and dilation of stomach or anastomoses, are significant contributors to WR.

Purpose of the Study:

  • To comprehensively review the mechanisms, risk factors, and management strategies for postoperative weight regain (WR) following bariatric surgery.
  • To emphasize the critical role of surgical considerations and potential revisional procedures in addressing WR.
  • To highlight the importance of distinguishing surgical issues from patient adherence for effective intervention.

Main Methods:

  • Systematic review of literature on bariatric surgery outcomes, focusing on weight regain.
  • Analysis of hormonal, metabolic, and surgical factors implicated in WR.
  • Evaluation of current management strategies, including lifestyle modifications, pharmacotherapy, and revisional surgery.

Main Results:

  • Hormonal adaptations (ghrelin rebound, leptin resistance) and metabolic changes (reduced resting energy expenditure) contribute to WR.
  • Surgical factors like inaccurate sizing, poorly calibrated anastomoses, and complications (e.g., fistulas, dilation) are key drivers of WR.
  • Effective management involves lifestyle interventions, pharmacotherapy (e.g., GLP-1 receptor agonists), and revisional surgery (e.g., sleeve-to-bypass, bypass revision).

Conclusions:

  • Postoperative weight regain after bariatric surgery is a complex issue influenced by biological and surgical factors.
  • A multidisciplinary approach combining lifestyle, pharmacotherapy, and potentially revisional surgery is essential for long-term weight management.
  • Careful surgical planning, patient selection, and timely intervention for anatomical failures are crucial for optimizing outcomes and improving patient quality of life.