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Related Experiment Video

Updated: May 11, 2026

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
11:43

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Published on: November 30, 2016

de novo metastases in patients with primary colorectal cancer: a Surveillance, Epidemiology, and End Results

Nicole C Loroña1, Kamya Sankar2, Mariana C Stern3

  • 1Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, 700 N. San Vicente Blvd. Suite G599, West Hollywood, Los Angeles, CA, 90069, USA. Nicole.Lorona@cshs.org.

Cancer Causes & Control : CCC
|April 19, 2025
PubMed
Summary
This summary is machine-generated.

Racial and ethnic disparities exist in colorectal cancer (CRC) metastasis patterns. Non-Hispanic Black patients showed higher odds of lung and liver metastases, while American Indian/Alaska Native patients had increased lung metastasis risk.

Keywords:
Colorectal cancerDisparitiesEarly-onsetEthnicityMetastaticRace

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Area of Science:

  • Oncology
  • Epidemiology
  • Cancer Research

Background:

  • Colorectal cancer (CRC) frequently presents as de novo metastatic disease (stage IV).
  • Certain metastatic sites and patient populations are associated with poorer prognoses.
  • Understanding disparities in metastatic patterns is crucial for targeted interventions.

Purpose of the Study:

  • To investigate associations between race/ethnicity and metastatic sites/patterns in de novo metastatic CRC.
  • To analyze these associations across different age groups: early-onset (<50), screen-eligible (50-74), and elderly (75-84).

Main Methods:

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database (2010-2020).
  • Analyzed 181,083 CRC cases, focusing on 43,054 with de novo metastatic disease.
  • Employed logistic and multinomial logistic regression to assess odds ratios for metastatic sites and patterns by race/ethnicity.

Main Results:

  • Liver was the most common metastatic site (80%).
  • Non-Hispanic Black patients had significantly higher odds of synchronous lung and liver metastases across all age groups compared to Non-Hispanic White (NHW) patients.
  • Early-onset American Indian/Alaska Native patients exhibited over double the odds of lung metastases compared to NHW patients.

Conclusions:

  • De novo metastatic CRC presentation and patterns vary significantly by race, ethnicity, and age.
  • Identifying at-risk populations for specific metastatic patterns is essential for prognosis and treatment.
  • This study highlights the need for tailored approaches to address disparities in advanced colorectal cancer.