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Research progress on ADAM28 in malignant tumors
Lanlan Zhao1, Wei Liu1, Fei Wang2
1Department of Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan, 250021, Shandong, China.
Abstract:
A disintegrin and metalloproteinase (ADAM) 28 belongs to the zinc-dependent metalloproteinase superfamily and has a signal sequence at its N-terminus that can direct the protein into the secretory pathway. ADAM28 is a multifunctional protein that has been shown to play a role in regulating numerous biological processes, including cell adhesion, cell fusion, membrane protein shedding, protein hydrolysis, and signaling pathway modulation. ADAM28 is highly expressed in numerous malignant tumors and plays a pivotal role in the proliferation, metastasis and drug resistance of these tumors by acting on substrates such as IGFBP-3, vWF and CTGF, thereby promoting PSGL-1/P-selectin-mediated cell adhesion. Consequently, inhibiting ADAM28 could impede tumor proliferation, metastasis and drug resistance, which suggests that ADAM28 may serve as a prognostic indicator of and potential therapeutic target for malignant tumors. In this article, the structure and function of ADAM28 and its correlation with the onset and progression of human malignant tumors are primarily examined. Additionally, the potential applications of ADAM28 in tumor research are investigated to offer a theoretical foundation and reference for the clinical diagnosis and treatment of malignant tumors.
Insights
A disintegrin and metalloproteinase (ADAM) 28 is a key protein in malignant tumors, driving proliferation and metastasis. Inhibiting ADAM28 shows promise for cancer therapy and diagnosis.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- ADAM28 is a metalloproteinase involved in cell adhesion, fusion, and protein shedding.
- It plays a role in various biological processes and signaling pathways.
Purpose of the Study:
- To examine the structure and function of ADAM28.
- To investigate its role in human malignant tumor development and progression.
- To explore its potential as a prognostic indicator and therapeutic target.
Main Methods:
- Literature review and analysis of existing research on ADAM28.
- Examination of ADAM28's substrates and mechanisms of action in cancer.
- Investigation of ADAM28's correlation with tumor characteristics.
Main Results:
- ADAM28 is highly expressed in malignant tumors.
- It promotes tumor proliferation, metastasis, and drug resistance.
- ADAM28 influences cell adhesion via substrates like IGFBP-3, vWF, and CTGF.
Conclusions:
- ADAM28 is a crucial factor in malignant tumor progression.
- Inhibiting ADAM28 may impede tumor growth and metastasis.
- ADAM28 holds potential as a prognostic biomarker and therapeutic target for cancer.
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