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Sulfonated covalent organic frameworks (COF)/polyethersulfone (PES) membrane with enhanced hemocompatibility for
Yue Huang1, Lunhao Zhi2, Chong Cheng2
1Sichuan University, College of Biomedical Engineering, Chengdu, Sichuan 610065, PR China.
Colloids and Surfaces. B, Biointerfaces
|April 19, 2025
Summary
Developing a novel sulfonated COF/PES membrane offers improved antithrombotic properties for extracorporeal membrane oxygenation (ECMO). This self-anticoagulant membrane enhances oxygen saturation and CO2 removal, reducing reliance on traditional anticoagulants.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Medical Device Engineering
Background:
- Extracorporeal membrane oxygenation (ECMO) treatment necessitates membranes with self-anticoagulant properties to mitigate risks associated with systemic anticoagulation.
- Current ECMO therapies face challenges due to the adverse effects of anticoagulant drugs, highlighting the need for innovative biomaterial solutions.
Purpose of the Study:
- To develop and evaluate a novel sulfonated Covalent Organic Framework (COF) film integrated onto a polyethersulfone (PES) membrane for enhanced antithrombotic performance in ECMO applications.
- To investigate the impact of sulfonic acid groups on membrane hydrophilicity, protein adhesion, blood cell morphology, and overall antithrombotic efficacy.
Main Methods:
- In situ growth of a sulfonated COF film using 2,4,6-Triformylphloroglucinol (Tp) and 2,5-Diaminobenzenesulfonic acid (Pa-SO3H) on a PES membrane.
- Characterization of the modified membrane's surface properties, including hydrophilicity and electronegativity.
- Evaluation of antithrombotic properties and blood compatibility through porcine blood circulation tests, assessing oxygen saturation (So2) and CO2 efflux.
Main Results:
- The sulfonated TpPa-SO3H COF/PES membrane (M-TpPa-SO3H) exhibited enhanced hydrophilicity, reduced protein adhesion, and maintained normal blood cell morphology.
- The M-TpPa-SO3H membrane demonstrated superior antithrombotic properties, significantly improving oxygen saturation levels more efficiently than the non-sulfonated counterpart.
- The preparation method proved adaptable for both flat and hollow fiber membranes, indicating broad applicability.
Conclusions:
- The M-TpPa-SO3H membrane presents a promising self-anticoagulant biomaterial for ECMO, offering improved oxygenation and CO2 removal capabilities.
- This COF-based membrane technology has the potential to enhance patient safety and treatment efficacy in ECMO by reducing the need for systemic anticoagulants.
