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Updated: May 12, 2025

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
Published on: April 6, 2022
Rapid penetrating inactivation and disinfection through ice layers by light-condensed deep ultraviolet LED
Lucheng Yu1, Peng Shen2, Zefeng Lin1
1Fujian Key Laboratory of Semiconductor Materials and Applications, CI Center for OSED, College of Physical Science and Technology, Xiamen University, Xiamen 361005, China.
Abstract:
The longer survival of virus and bacteria under low temperature greatly accelerates the infection risk and duration. How to effectively and rapidly inactivate them beneath ice layer in cold chain logistics has been an important issue never being well studied. Here, we demonstrate a novel light condenser design of high power UVC-LED device for rapid penetrating inactivation through ice layers. With fish-scale, ellipsoidal and alumina coated condenser, a portable UVC (275 nm) LED device in ultrahigh light output power (> 3 W) was fabricated in a narrowed propagation angle (< 60o). Such condensed light beams are able to overcome the interfacial refringence at the ice and bubble interfaces in different types of ice layers for enhancing the transmission rate. As a result, the penetrating UVC light could give rise to the effective necrosis and apoptosis influence as well as DNA/RNA destruction on cells. A 99.99 % inactivation rate of Escherichia coli and Staphylococcus aureus has been obtained through 5-mm-thickness opaque ice layer. By 1.5 s irradiation, SARS-COV-2 virus can be completely inactivated and disinfected. This work proved the strong power of UVC-LED for cold chain disinfection applications.
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