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Updated: May 12, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
Polyphenol briged bimetallic-heterostructure inducing chiral peroxidase nanozyme activity for enantiomers
Qiu-Hong Yao1, Mei-Huang Zeng2, Chen Zhang1
1Institute of Analytical Technology and Smart Instruments and Colleague of Environment and Public Healthy, Xiamen Huaxia University, Xiamen, 361024, China.
Abstract:
D-alanine (D-Ala) and D-proline(D-Pro) levels dramatically increase in the bio-fluids of gastric cancer (GC) patients, which are suggested to be potential biomarkers associated with GC. Therefore, monitoring the concentrations of D-Pro and D-Ala in the body fluids of GC patients is of great significance. In this study, a highly sensitive Surface Enhanced Raman Scattering (SERS) sensor has constructed based on bimetallic heterostructure nanoenzyme (3-MPBA: Co-TA@Ag NPs) for D-AAs detection in GC bio-fluids. Attributing to the formation of Ag-Co bimetallic dual active centers, the electron transfer behaviors accelerated boron hydroxyl group ionization in neutral pH, as well as the ultra-robust hydroxyl alcohol esterification reaction occurred between D-Ala and D-Pro and 3-MPBA. By simply testing different absorbance intensities at various concentrations and sample, a sensor for noninvasive detection of D-Pro/Ala is constructed with good specificity and efficiency. Besides, the quantitative determination of D-Pro/Ala (limits of detection (LOD) 2.37 μM and 2.15 μM for D-Pro/Ala. Furthermore, based on the differential level of D-Pro/Ala in GC bio-fluids, the differentiation of saliva samples with D-Pro/Ala can also be implemented by the proposed method, showing great potential in GC diagnosis.
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