Recent advances and challenges in graphene-based electrochemical biosensors for food safety

Ensuring food safety is a critical global concern, particularly in light of recent pandemics and rising contamination risks from pesticides, antibiotics, toxins, and allergens. These contaminants pose significant health hazards, including neurological disorders, endocrine disruption, antibiotic resistance, and carcinogenic effects. Regulatory agencies such as the Food and Agriculture Organization (FAO), the World Health Organization (WHO), and the United States Food and Drug Administration (FDA) have established strict maximum residue limits (MRLs) to mitigate these risks. However, enforcement remains challenging due to limitations in current detection methods. The increasing global population and limited food resources have exacerbated food security challenges, while contaminants can infiltrate food at various stages, including production, processing, and packaging. Despite consumer awareness, significant amounts of food are discarded due to quality concerns. To address these issues, researchers are actively developing low-cost, reliable sensing technologies for real-time food quality assessment and contamination detection. Among these, graphene-based electrochemical biosensors have emerged as a promising solution due to their high sensitivity, selectivity, and cost-effectiveness. This review provides an in-depth analysis of recent advancements in graphene-based electrochemical biosensors, focusing on their role in detecting foodborne hazards and improving food quality monitoring. By integrating selective layers, these sensors enhance detection efficiency and provide an innovative solution for safeguarding public health. The findings underscore the transformative potential of graphene-derived biosensors in food safety diagnostics, paving the way for more reliable and sustainable food monitoring systems.