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Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Disrupted structural network resilience in atherosclerosis: A large-scale cohort study.
Hui Tang1, Wanlin Zhu2, Jing Jing2
1Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Brain Research
|April 19, 2025
Summary
Atherosclerosis impacts brain network resilience and cognitive function. Structural network resilience (SNR) is a potential biomarker for cognitive decline in aging individuals with atherosclerosis.
Area of Science:
- Neuroscience
- Vascular Biology
- Cognitive Aging
Background:
- Atherosclerosis is a key contributor to age-related cognitive decline, often associated with white matter hyperintensities.
- The impact of atherosclerosis on brain resilience and its subsequent effect on cognition is not well understood.
- This study explores the interplay between atherosclerosis, white matter changes, and brain network resilience in relation to cognitive performance.
Purpose of the Study:
- To investigate the relationship between atherosclerosis, white matter hyperintensities, and structural network resilience.
- To examine the combined effects of these factors on cognitive function in aging individuals.
- To identify potential biomarkers for cognitive decline in the context of atherosclerosis.
Main Methods:
- Utilized data from the Polyvascular Evaluation for Cognitive Impairment and Vascular Events cohort (n=2160).
- Constructed whole-brain structural networks and simulated disconnections based on white matter hyperintensities.
- Quantified structural network resilience using Structural Network Resilience (SNR), defined by hub node similarity before and after simulated disconnection.
Main Results:
- Structural Network Resilience (SNR) demonstrated stronger associations with arterial status than white matter hyperintensities.
- Cognitive decline linked to atherosclerosis was partially mediated by both white matter hyperintensities and reduced structural network resilience.
- Atherosclerosis accelerates the decline of brain structural network resilience with increasing age.
Conclusions:
- Structural Network Resilience (SNR) provides valuable insights into atherosclerosis-related cognitive decline and may serve as a biomarker for brain health.
- SNR could potentially guide therapeutic strategies for managing atherosclerosis and its cognitive consequences.
- Understanding brain resilience is crucial for addressing cognitive impairment in aging populations affected by vascular conditions.
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