Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

1.2K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-Organ Dysfunction in Neonatal Hypoxic Ischemic Encephalopathy and Brain Magnetic Resonance Imaging Outcomes.

Pediatric neurology·2026
Same author

Validation of Automated Software for Guttae Quantification in Fuchs Endothelial Corneal Dystrophy.

Translational vision science & technology·2026
Same author

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9.

Annals of clinical and translational neurology·2026
Same author

ACT for postsurgical pain and dysfunction in at-risk veterans: Multisite, double-blind, cluster RCT.

Journal of psychosomatic research·2025
Same author

Immunisation recommendations for children with single ventricle CHD.

Cardiology in the young·2025
Same author

The significant impact of the distal ureteral diameter ratio as predictor of breakthrough urinary tract infections in children with vesicoureteral reflux.

Journal of pediatric urology·2025

Related Experiment Video

Updated: May 20, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

828

Outcome Disparities Between Rural and Urban Infants with Single-Ventricle Heart Disease.

Janelle Buysse1, Trudy A Pierick1, M Bridget Zimmerman2

  • 1Division of Pediatric Cardiology, Department of Pediatrics, University of Iowa, Iowa City, IA.

The Journal of Pediatrics
|April 19, 2025
PubMed
Summary

Rural infants with single-ventricle heart disease show better transplant-free survival. While urban infants have better growth, this difference is linked to demographics and disease severity, not location itself.

Keywords:
growthhypoplastic left heart syndromeruralsingle ventricleurban

More Related Videos

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
04:37

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications

Published on: June 16, 2023

1.0K
Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.3K

Related Experiment Videos

Last Updated: May 20, 2025

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

828
Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications
04:37

Author Spotlight: Effect of Left Atrial Ligation on Avian Embryonic Hearts and HLHS Implications

Published on: June 16, 2023

1.0K
Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging
07:13

Author Spotlight: Advancing Neonatal Cardiac Diagnostics with Echocardiography-Derived Blood Speckle Imaging

Published on: December 22, 2023

1.3K

Area of Science:

  • Pediatric Cardiology
  • Public Health
  • Health Outcomes Research

Background:

  • Single-ventricle heart disease (SVHD) presents unique challenges for infant growth and survival.
  • Environmental factors, such as urban vs. rural home location, may influence health outcomes in these vulnerable infants.
  • Understanding these disparities is crucial for targeted interventions and improved care.

Purpose of the Study:

  • To investigate the association between urban or rural home location and somatic growth (weight and height z scores) in infants with SVHD at one year of age.
  • To evaluate the impact of home location on transplant-free survival at one year in infants with SVHD.
  • To identify potential confounding factors influencing growth and survival based on geographic location.

Main Methods:

  • Retrospective analysis of 1754 infants with SVHD from 67 centers (2016-2020) using the National Pediatric Cardiology-Quality Improvement Collaborative database.
  • Home location classified as urban or rural based on Rural-Urban Commuting Area codes.
  • Comparison of one-year weight/height z scores and transplant-free survival between urban and rural groups, with adjusted analyses for covariates and subgroup analyses.

Main Results:

  • Urban infants exhibited significantly greater weight and height z scores at one year compared to rural infants (P < .01).
  • After adjusting for covariates, these growth differences were no longer statistically significant (P = .21 for weight, P = .15 for height).
  • Rural infants demonstrated significantly higher odds of one-year transplant-free survival compared to urban infants (OR 0.72, P < .02).

Conclusions:

  • Infants with SVHD living in rural areas experience superior transplant-free survival to their first birthday.
  • While urban infants show initially better growth, this disparity is explained by demographic and disease severity factors, not solely by location.
  • Environmental context plays a role in SVHD outcomes, highlighting the need for location-aware healthcare strategies.