Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 10, 2025

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

401

"Thin endometrium" at single-cell resolution.

Xiwen Zhang1, Haining Lv1, Qiao Weng1

  • 1Center for Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

American Journal of Obstetrics and Gynecology
|April 19, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

L-carnosine attenuates endometrial fibrosis by targeting the ERK/PTGS2 axis.

European journal of pharmacology·2026
Same author

Single-nucleus RNA sequencing reveals molecular determinants of functional and physiological differences between extraocular and quadriceps muscles in Macaca fascicularis.

Genomics·2026
Same author

CD81 restricts decidual IGF2-mediated smooth muscle cell dedifferentiation during spiral artery remodeling in preeclampsia.

BMC medicine·2026
Same author

Aerobic Exercise-Induced TGF-β Receptor Reprogramming Disrupts Neutrophil-Microglia Crosstalk to Attenuate Early Brain Injury after Subarachnoid Hemorrhage.

Research (Washington, D.C.)·2026
Same author

Persistent compression of uterine insertion on maternal blood dynamic change in fetoscopic laser photocoagulation surgery: a novel method.

BMC pregnancy and childbirth·2026
Same author

FGFR2-responsive self-assembled hydrogel releases its inhibitor to suppress the progression of endometriosis.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same journal

Early patient removal of urinary catheters after urogynecologic surgery, a randomized trial.

American journal of obstetrics and gynecology·2026
Same journal

Standard vs. Lower Pressure Pneumoperitoneum in Laparoscopic Gynecologic Surgery: A Randomized Controlled Trial.

American journal of obstetrics and gynecology·2026
Same journal

Association of Surgical Approach with Oncologic Outcomes in Low-Risk Cervical Cancer.

American journal of obstetrics and gynecology·2026
Same journal

Trends in Infertility Treatments by Race, Ethnicity, Socioeconomic Status, and Region in U.S. Birth Certificates from Live Births: 2011-2022.

American journal of obstetrics and gynecology·2026
Same journal

Likelihood ratios enhance clinical interpretation of metagenomic prediction of early-onset neonatal sepsis in preterm premature rupture of membranes (Letter-to-the-Editor).

American journal of obstetrics and gynecology·2026
Same journal

Taking risk stratification in preterm premature rupture of membranes to the bedside (Reply to Letter-to-the-Editor).

American journal of obstetrics and gynecology·2026
See all related articles

Thin endometrium, often caused by uterine injury, leads to infertility. Research suggests accelerated cellular aging and immune dysfunction contribute to this condition, hindering pregnancy.

Area of Science:

  • Reproductive Biology
  • Cellular Biology
  • Gynecology

Background:

  • Thin endometrium (<7 mm) impairs uterine receptivity and pregnancy, especially in infertility treatments.
  • Estrogen therapy shows limited success in improving endometrial thickness and pregnancy rates.
  • Refractory thin endometrium necessitates understanding underlying mechanisms for new therapies.

Purpose of the Study:

  • To review recent single-cell sequencing studies on thin endometrium.
  • To identify cellular and molecular alterations in thin endometrium post-uterine injury.
  • To explore potential therapeutic targets for improving endometrial receptivity.

Main Methods:

  • Analysis of single-cell sequencing data from late proliferative phase endometrium.
  • Comparison of cell populations, signaling pathways, and cell-cell communication in normal vs. thin endometrium.
Keywords:
FOXO1SASPcellular senescencedysangiogenesisendometrial fibrosisendometrial proliferationendometrial thicknessimmune microenvironmentsenolyticssingle-cell sequencinguterine infertility

More Related Videos

Generation of Multicellular Human Primary Endometrial Organoids
09:20

Generation of Multicellular Human Primary Endometrial Organoids

Published on: October 4, 2019

10.8K
Establishing 3D Endometrial Organoids from the Mouse Uterus
06:24

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

5.9K

Related Experiment Videos

Last Updated: May 10, 2025

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses
07:03

An Efficient Method for Extracting Human Fallopian Tube Epithelia for Single-cell Analyses

Published on: March 28, 2025

401
Generation of Multicellular Human Primary Endometrial Organoids
09:20

Generation of Multicellular Human Primary Endometrial Organoids

Published on: October 4, 2019

10.8K
Establishing 3D Endometrial Organoids from the Mouse Uterus
06:24

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

5.9K
  • Review of evidence linking endometrial injury to cellular aging and immune dysfunction.

    • Main Results:

    • Endometrial injury accelerates cellular aging and causes immune incompetence in the endometrium.
    • Senescence impedes endometrial proliferation, vascularization, and promotes fibrosis.
    • These changes create an environment hostile to implantation, leading to infertility.

    Conclusions:

    • Endometrial injury-induced cellular senescence is a key factor in refractory thin endometrium.
    • Targeting senescence and immune dysfunction may offer novel therapeutic strategies.
    • Further research is crucial for clinical translation to improve pregnancy outcomes.