Correlation between serum thyroid hormone level and metabolic steatohepatitis: A retrospective study

Area of Science:

• Hepatology
• Endocrinology
• Internal Medicine

Background:

• Metabolic steatohepatitis (MASH) is a prevalent liver condition.
• The relationship between MASH and thyroid hormone levels remains unclear.
• This study investigates MASH in patients with normal thyroid function.

Purpose of the Study:

• To analyze the association between MASH and serum thyroid hormone levels.
• To identify thyroid hormone profiles linked to MASH development.
• To assess the predictive value of thyroid hormones for MASH.

Main Methods:

• Retrospective analysis of 638 non-alcoholic fatty liver disease patients.
• Patients categorized into MASH (n=262) and non-MASH (n=376) groups.
• Multivariate logistic regression used to examine MASH and thyroid hormone associations.

Main Results:

• MASH patients showed significantly higher serum TSH and FT3 levels.
• MASH patients exhibited lower serum FT4 levels.
• Elevated FT3/FT4 ratio and TSH, FT3, FT4 levels were independent MASH predictors (ROC AUCs: 0.944-0.973).

Conclusions:

• Increased serum TSH, FT3, and FT3/FT4 ratio are associated with MASH.
• Decreased serum FT4 levels are also linked to an elevated MASH risk.
• Thyroid hormone levels are independent predictors of MASH occurrence.