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Related Experiment Video

Updated: May 10, 2025

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Development of Amelogenin-chitosan Hydrogel for In Vitro Enamel Regrowth with a Dense Interface

Published on: July 10, 2014

Plexiform ameloblastoma: a potential diagnostic challenge.

Michelle Huang¹, Grace Bradley¹, Bayardo Perez-Ordonez²

¹Oral Pathology and Oral Medicine, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

|April 19, 2025

Summary

This summary is machine-generated.

This study identifies a rare plexiform ameloblastoma pattern challenging for pathologists. BRAF mutation testing is crucial for accurate diagnosis of this jaw neoplasm.

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Last Updated: May 10, 2025

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Systematic Assessment of Mammalian Skull Specimens for Dental and Temporomandibular Joint Pathology

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Published on: August 22, 2022

Area of Science:

Oral pathology
Oncology
Histopathology

Background:

Ameloblastoma is a locally aggressive jaw neoplasm requiring accurate diagnosis.
Rare plexiform patterns can mimic less aggressive lesions, complicating diagnosis.
Diagnostic challenges arise from plexiform ameloblastomas lacking pathognomonic features.

Purpose of the Study:

To review challenging cases of plexiform ameloblastoma.
To identify diagnostic features of uncommon ameloblastoma variants.
To improve diagnostic accuracy for difficult jaw lesions.

Main Methods:

Reviewed 200 ameloblastoma cases from 2004-2024.
Analyzed cases with cystic plexiform epithelial proliferation.
Correlated histopathology with clinical and radiographic data.

Main Results:

Identified a rare subset (4%) with plexiform patterns lacking ameloblast-like cells.
Clinical and radiographic features were characteristic of ameloblastoma.
BRAF p.V600E mutation was positive in 7 of 8 cases, aiding diagnosis.

Conclusions:

Highlights an uncommon, challenging ameloblastoma histologic pattern.
Emphasizes the need for integrated diagnostic approaches.
Recommends combining clinical, radiographic, histologic, and molecular data for diagnosis.