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Updated: Jun 29, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

Spatial transcriptomics study of Castleman disease.

Yanfang Chen¹, Zhe Zhang², Ling Li¹

¹Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Journal of Translational Medicine

|April 19, 2025

Summary

This summary is machine-generated.

Spatial transcriptomics reveals Castleman Disease (CD) pathogenesis, suggesting B cells are lesion cells and myofibroblasts drive progression. This offers new avenues for CD research and drug development.

Keywords:

Castleman disease Heterogeneity Lesion cells Pathogenesis Spatial transcriptome

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Area of Science:

Immunology
Pathology
Genomics

Background:

Castleman Disease (CD) is a rare lymphoproliferative disorder with unknown causes, typically presenting as painless lymphadenopathy.
Understanding the pathogenesis of CD is crucial for developing effective treatments.

Purpose of the Study:

To investigate the pathogenesis of Castleman Disease (CD) using spatial transcriptomics.
To identify key cellular players and interactions in CD development.

Main Methods:

Spatial transcriptomics analysis was performed on formalin-fixed paraffin-embedded (FFPE) lymph node samples.
Samples included three CD patients with diverse histologic types and one normal lymph node for comparison.

Main Results:

Fourteen distinct cell clusters were identified, including B cells, plasma cells, various immune cells, and mesenchymal cells.
Evidence suggests B cells may be the primary lesion cells in CD.
Mesenchymal cells, particularly myofibroblasts, were found to be significant in disease progression, with notable heterogeneity in cellular communication across different CD subtypes.

Conclusions:

This study enhances the understanding of Castleman Disease pathogenesis.
Findings provide novel insights for future CD research and the development of targeted therapies.