Related Experiment Video
Updated: May 10, 2025
08:45
Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry
Published on: April 21, 2022
2.3K
Interactions between long non-coding RNAs and m6 A modification in cancer.
Han Zhang1,2, Junjie Wang3, Chunyi Liu1
1Department of Biochemistry and Molecular Biology, Jiangsu University School of Medicine, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China.
Discover Oncology
|April 20, 2025
Summary
Long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6 A) RNA modifications interact dynamically, influencing cancer progression and drug resistance. Understanding this interplay offers new diagnostic and therapeutic strategies for cancer.
Area of Science:
- Molecular Biology
- Epigenetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) regulate diverse cellular processes, including oncogenesis.
- N6-methyladenosine (m6 A) is a key RNA modification impacting RNA biology and cancer progression.
Purpose of the Study:
- To elucidate the intricate functions and mechanisms of lncRNA-m6 A interactions in cancer.
- To explore the potential of targeting lncRNA-m6 A interplay for cancer diagnosis and therapy.
Main Methods:
- Literature review and synthesis of current research on lncRNAs and m6 A modifications in cancer.
- Analysis of the impact of their interactions on oncogenes, tumor suppressors, and cancer hallmarks.
Main Results:
- lncRNAs modulate m6 A regulator activity, while m6 A affects lncRNA structure, translation, and stability.
- These interactions influence tumorigenesis, metastasis, drug resistance, and epigenetic regulation.
Conclusions:
- The interplay between lncRNAs and m6 A modifications is crucial in cancer development and progression.
- Targeting these interactions presents promising avenues for novel cancer therapeutic strategies.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
8.4K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.4K
01:22MicroRNAs
2.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
2.9K
01:53RNA Stability
33.0K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.0K
01:20Types of RNA
5.5K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.5K
01:37Epigenetic Regulation
2.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
2.9K
01:32RNA Splicing
55.7K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
55.7K