Related Experiment Video For Penis
Updated: Jun 14, 2025
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Metastatic Prostatic Adenocarcinoma to the Penis with Diffuse P16 Expression: Recognizing a Diagnostic Pitfall
Levente Kuthi, Márton Csaba Gráczia1,2,3, Imola Adamik1
1Department of Surgical and Molecular Pathology, Tumor Pathology Center, National Institute of Oncology, Budapest, Hungary.
Introduction:
Prostate cancer (PCa) is the most common malignant tumor in men, with acinar adenocarcinoma as the predominant subtype. While PCa metastases typically affect bones, penile metastases are exceedingly rare. Penile tumors are generally squamous cell carcinoma (SCC), with p16 overexpression often used as a surrogate marker for oncogenic human papillomavirus (HPV) infection.
Case Presentation:
We report the case of an 85-year-old male with a history of PCa (grade group 5) treated with irradiation and hormonal therapy, who presented with a progressive penile lesion initially misdiagnosed as HPV-associated SCC. Immunohistochemistry revealed diffuse panCK, p16, NKX3.1, androgen receptor, and ERG positivity, with Rb1 protein loss confirming metastatic PCa. Prostate-specific antigen levels remained within the normal range, complicating the diagnosis.
Conclusion:
This case emphasizes the importance of thorough clinicopathological correlation in unusual metastatic presentations and highlights that p16 overexpression, even in penile tumors, may indicate Rb1 inactivation rather than HPV-related SCC.
