Seventy years of coexistence: Parasites and Mediterranean fish aquaculture

What can be regarded as a seedling of the contemporary aquaculture in the Mediterranean began back in the 1950s. The development of the industry did not always align with the development of ichthyopathology, a veterinary discipline aimed at identifying and combating fish diseases. Therefore, and due to the lack of published data, we are not always able to pinpoint the first outbreaks that accompanied the increase in aquaculture production. Nonetheless, fish pathogens, and parasites in particular, have shown diversity related to host species, their farming conditions and geography. Two parasite species currently regarded as dominant in Mediterranean aquaculture are the histozoic myxozoan Enteromyxum leei and the haematophagous polyopisthocotylean Sparicotyle chrysophrii, both of which infect gilthead seabream (Sparus aurata). The interactions between parasite and host with regard to the immune activity of both have been well studied using conventional immunology and omics approaches. For the remaining parasite-fish systems, our understanding of host responses and parasite mitigation mechanisms is still vague and mostly transposed from what we know of other systems. This review compiles the knowledge on fish response to the most frequent and economically important parasites in Mediterranean aquaculture, highlights the gaps and suggests further directions.