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Clinical Impact of Tirzepatide on Patients With OSA and Obesity

Jheng-Yan Wu1, Chia-Chen Chen2, Wan-Ling Tu3

  • 1Department of Nutrition, Tainan, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Chest
|April 20, 2025
PubMed
Abstract

Insights

Tirzepatide significantly reduced mortality, cardiovascular events, and kidney complications in patients with obstructive sleep apnea (OSA) and obesity. This study highlights tirzepatide as a promising treatment for improving health outcomes in this high-risk population.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology
  • Pulmonology
  • Metabolic Diseases

Background:

  • Obstructive sleep apnea (OSA) is a common condition associated with obesity, increasing risks for cardiovascular and kidney diseases.
  • While weight loss aids OSA management, novel therapeutic strategies are needed.
  • Tirzepatide, a dual GIP and GLP-1 receptor agonist, demonstrates potential for substantial weight reduction and OSA symptom improvement.

Purpose of the Study:

  • To investigate the impact of tirzepatide on clinical outcomes in individuals diagnosed with OSA and obesity.
  • To evaluate tirzepatide's effect on all-cause mortality, major adverse cardiovascular events (MACEs), and major adverse kidney events (MAKEs) in this patient cohort.

Main Methods:

  • A retrospective cohort study utilizing the TriNetX Global Collaborative Network.
  • Included adults with OSA and obesity, comparing patients prescribed tirzepatide against those receiving lifestyle interventions.
  • Propensity score matching (PSM) was employed to ensure balanced covariates between the study and control groups.

Main Results:

  • The study analyzed 42,300 patients post-PSM (21,150 per group).
  • Tirzepatide use was linked to significantly lower risks of all-cause mortality (HR 0.443), MACEs (HR 0.731), and MAKEs (HR 0.427).
  • These benefits were consistent across various age, sex, BMI, and CPAP use subgroups, except for the 18-39 age group.

Conclusions:

  • Tirzepatide may reduce mortality, cardiovascular events, and kidney complications in patients with OSA and obesity.
  • These findings suggest tirzepatide as a potential therapeutic option for enhancing clinical outcomes in this population.
  • Further research is warranted to confirm these benefits and explore optimal use in OSA management.
Keywords:
OSAobesitytirzepatide

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