Effect of Bisphenol A on the neuro-immune-endocrine mechanisms controlling the reproductive axis response during an
Romina Penalba1, Juan Manuel Gamez1, Nancy Cardoso1
1Laboratory of Endocrinology, II Academic Unity of Physiology, School of Medicine, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
Abstract:
Endotoxin-induced toxicity could increase with previous exposure to sensitizing agents like endocrine disruptors (EDs). We studied the effects on the reproductive axis on adult male rat pups exposed to BPA since gestation day (GD) 1 to final lactation and its response to LPS before sacrifice. The decrease in GnRH release caused by LPS and BPA was more pronounced in the BPA + LPS group compared to the LPS-only group. While LPS increased nitrate production, the addition of BPA lowered it compared to both the control and LPS groups. A reduction in plasma LH levels was observed in the control, BPA + LPS, and LPS groups. Plasma testosterone decreased in the LPS, BPA, and BPA + LPS groups compared to the control, and in the BPA + LPS group compared to the LPS group. In conclusion, BPA disrupts the reproductive function and sensitizes it to LPS-induced toxicity.
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