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Related Concept Videos

Dementia01:30

Dementia

65
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
317
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

128
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
128

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Related Experiment Video

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Association between herpes simplex virus 1 and dementia: a systematic review protocol.

Alexander T Hong1, Ivan Yun-Kuen Luu1, Forest Lin1

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Herpes simplex virus 1 (HSV-1) is common and may be linked to dementia. This review examines HSV-1

Keywords:
DementiaEPIDEMIOLOGIC STUDIESEpidemiologyInfectious disease/HIVPublic health

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Area of Science:

  • Neuroscience
  • Virology
  • Epidemiology

Background:

  • Herpes simplex virus 1 (HSV-1) is highly prevalent globally, affecting two-thirds of individuals under 50.
  • The association between HSV-1 infection and neurodegenerative diseases, particularly dementia and Alzheimer's disease, is not well understood.

Purpose of the Study:

  • To elucidate the potential link between HSV-1 infection and dementia.
  • To explore the benefits of preventing or treating herpesvirus infections in reducing dementia risk.
  • To enhance understanding of HSV-1's role in dementia for future therapeutic development.

Main Methods:

  • Systematic review of multiple databases (PubMed, Embase, Web of Science, Scopus, etc.) from inception.
  • Inclusion criteria: studies with HSV-1 exposure and dementia/subtypes as outcomes.
  • Data extraction, risk of bias assessment (Cochrane), and evidence quality evaluation (GRADE); random-effects model meta-analysis planned.

Main Results:

  • This section is to be populated upon completion of the systematic review and data analysis.
  • Expected to synthesize findings on HSV-1 exposure and dementia risk across various populations and subtypes.

Conclusions:

  • This review will provide insights into the relationship between HSV-1 and dementia.
  • Findings may inform strategies for dementia prevention and treatment by targeting herpesvirus infections.