Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Structure01:45

Kidney Structure

66.8K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
66.8K
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

1.1K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.1K
Renal Corpuscle01:20

Renal Corpuscle

1.2K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.2K
Nephrons01:10

Nephrons

1.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
1.5K
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

513
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
513
Filtration and Urine Formation01:32

Filtration and Urine Formation

47.6K
The function of the kidneys is to filter, reabsorb, secrete, and excrete. Every day the kidneys filter nearly 180 liters of blood, initially removing water and solutes but ultimately returning nearly all filtrates into circulation with the help of osmoregulatory hormones. This process removes wastes and toxins but is also crucial to maintain water and electrolyte levels. Most of these functions are performed by the tiny but numerous nephrons contained within the kidneys.
47.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular characterization of Cdh12-SCON conditional knockout mice reveals unexpected splicing changes.

Transgenic research·2026
Same author

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling.

Nature genetics·2026
Same author

Glycine-to-aspartic acid mutation at codon 51 in <i>Snca</i> disrupts the synaptic localisation of α-synuclein and enhances its propensity for synucleinopathy.

Brain communications·2025
Same author

A novel knockout mouse model to assess the impact of one-copy loss of Hnrnpk in CD4 + T cells in chronically inflamed skin as a prelude to CTCL.

Scientific reports·2025
Same author

The etiology of congenital obstructive uropathy: developmental and genetic perspectives.

Current topics in developmental biology·2025
Same author

A high-fidelity microfluidic platform reveals retrograde propagation as the main mechanism of α-Synuclein spread in human neurons.

NPJ Parkinson's disease·2025

Related Experiment Video

Updated: May 10, 2025

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

9.7K

Understanding developing kidneys and Wilms tumors one cell at a time.

Nine Solee Pop1, Karamjit Singh Dolt1, Peter Hohenstein1

  • 1Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.

Current Topics in Developmental Biology
|April 20, 2025
PubMed
Summary

Single-cell sequencing is transforming biomedical research, offering new insights into kidney development and Wilms tumor. This review clarifies available techniques for researchers studying these complex biological processes.

Keywords:
EpigenomicsKidney developmentMultimodalSignalomicsSingle-cellSpatialTranscriptomicsTranslatomicsWilms tumor

More Related Videos

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
06:29

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

477
Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

4.5K

Related Experiment Videos

Last Updated: May 10, 2025

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

9.7K
Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression
06:29

Microfluidic Co-culture of Renal Healthy and Tumor Epithelium to Model Kidney Cancer Progression

Published on: January 31, 2025

477
Generation of Human Kidney Tubuloids from Tissue and Urine
08:34

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

4.5K

Area of Science:

  • Biomedical Sciences
  • Developmental Biology
  • Genomics

Background:

  • Single-cell sequencing techniques are increasingly vital across biomedical sciences.
  • Understanding normal kidney development and Wilms tumor pathogenesis is crucial.
  • Numerous single-cell sequencing methods exist, creating complexity for researchers.

Purpose of the Study:

  • To review available single-cell sequencing techniques.
  • To discuss their application in kidney development and Wilms tumor research.
  • To guide the optimal combination of techniques for enhanced biological understanding.

Main Methods:

  • Literature review of single-cell sequencing technologies.
  • Analysis of studies applying these techniques to kidney development and Wilms tumor.
  • Discussion of synergistic potential between different single-cell methods.

Main Results:

  • Overview of current single-cell sequencing platforms.
  • Evaluation of their utility in the context of kidney development and Wilms tumor.
  • Identification of potential combinations for deeper biological insights.

Conclusions:

  • Single-cell sequencing offers powerful tools for studying kidney development and Wilms tumor.
  • Careful selection and combination of techniques are essential for maximizing research impact.
  • Further integration of methods will advance understanding of these biological systems.