Kidney organoids: a 3-dimensional tool to unmask permeability factors in primary and recurrent FSGS

Primary focal segmental glomerulosclerosis is a glomerular disorder associated with a high risk of recurrence after transplantation. Compelling evidence supports the existence of circulating permeability factors whose identity remains elusive. In the current issue of Kidney International, Gupta et al. propose that kidney organoid can respond to these factors in patients with focal segmental glomerulosclerosis and may serve as a potential platform for predicting disease recurrence. Future studies are required to identify the critical factors driving focal segmental glomerulosclerosis recurrence and to develop a standardized organoid platform for predicting clinical outcome.