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The heterogeneity of cirrhosis - systemically assessed endotypes described by fibrosis, apoptosis, and immunoregulatory-related biomarkers

  • 0Nordic Bioscience A/S, Herlev Hovedgade 205-207, Herlev, Denmark; Department of Biomedical Sciences, University of Copenhagen, Denmark.
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver +

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April 20, 2025

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April 20, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Biomarkers for fibrogenesis, apoptosis, and inflammation reveal distinct cirrhosis endotypes. These findings may improve patient monitoring and treatment selection for advanced chronic liver disease.

Area Of Science

  • Hepatology and Gastroenterology
  • Molecular Biology
  • Immunology

Background

  • Advanced chronic liver disease (cirrhosis) is heterogeneous.
  • Identifying distinct cirrhosis endotypes is crucial for personalized patient management.
  • Disease activity biomarkers can help classify these endotypes.

Purpose Of The Study

  • To investigate cirrhosis endotypes using biomarkers of fibrogenesis, immune cell activity, apoptosis, and systemic inflammation.
  • To correlate these biomarkers with disease severity and portal hypertension.

Main Methods

  • Plasma samples from 106 cirrhosis patients and 39 controls were analyzed.
  • Biomarkers measured included PROC3 (fibrogenesis), GDF-15, CK18 M30 (apoptosis), CRP (inflammation), CPa9-HNE (neutrophil activity), and VICM (macrophage activity).
  • Hepatic venous pressure gradient (HVPG) was measured to assess portal hypertension.

Main Results

  • Biomarkers for fibrogenesis (PROC3), apoptosis (GDF-15, CK18 M30), and inflammation (CRP) increased with cirrhosis severity and portal hypertension.
  • Neutrophil activity (CPa9-HNE) and macrophage activity (VICM) showed inverse correlations with disease severity and portal hypertension.
  • Clustering analysis identified four potential cirrhosis endotypes based on these molecular patterns.

Conclusions

  • Distinct molecular patterns associated with fibrogenesis, apoptosis, immune activity, and inflammation were observed in cirrhosis patients.
  • These patterns suggest the existence of specific cirrhosis endotypes.
  • These endotypes could guide future strategies for cirrhosis monitoring, treatment selection, and prognosis.

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