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Untargeted Metabolomics from Biological Sources Using Ultraperformance Liquid Chromatography-High Resolution Mass Spectrometry UPLC-HRMS
Published on: May 20, 2013
Pharmacokinetics of Oleracrylimide E in Rats Plasma Using UHPLC/-ESI-Q-TOF/MS
Zheming Ying1, Kaiyun Jiang1, Chengyu Wang2
1School of Traditional Chinese Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Abstract:
Oleracrylimide E, a new alkaloid from Portulaca oleracea L., shows significant bioactivity. Then, the pharmacokinetics of this alkaloid after its intravenous administration at dose of 2.0 mg/kg body weight in rat plasma was evaluated using UHPLC with vitexin-2″-O-rhamnoside as an internal standard (IS). The UHPLC-ESI-Q-TOF/MS method was applied to investigate the metabolism of Oleracrylimide E in rats in response to the immediate conversion of Oleracrylimide E into other metabolites after its oral administration. As a result, a total of 16 metabolites of Oleracrylimide E were identified in the plasma, urine, and fecal of the experimental rats.
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