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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Related Experiment Video

Updated: May 10, 2025

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Disulfidptosis-related LncRNAs forecast the prognosis of acute myeloid leukemia.

Pei Xu1, Xiaolin Sun2, Lingxiao Pan1

  • 1Department of Hematology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.

Scientific Reports
|April 20, 2025
PubMed
Summary
This summary is machine-generated.

This study identifies a prognostic signature of seven disulfidptosis response-related long non-coding RNAs (DRLs) for acute myeloid leukemia (AML). This signature effectively predicts patient prognosis and reveals immune microenvironment differences in AML.

Keywords:
Acute myeloid leukemiaDisulfidptosisImmune microenvironmentLncRNAsPrognostic signature

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Area of Science:

  • Hematologic Malignancies
  • Molecular Oncology
  • Immunogenomics

Background:

  • Acute myeloid leukemia (AML) is an aggressive cancer with poor outcomes.
  • Disulfidptosis response-related long non-coding RNAs (DRLs) are implicated in cancer progression.

Purpose of the Study:

  • To develop a prognostic DRL signature for AML.
  • To explore the immune microenvironment in AML based on DRLs.

Main Methods:

  • Utilized RNA-seq and clinical data from The Cancer Genome Atlas (TCGA) database.
  • Constructed and validated a prognostic model using seven DRLs.
  • Performed KEGG and immune infiltration analyses.

Main Results:

  • A robust seven-lncRNA prognostic model was developed, distinguishing high-risk and low-risk AML patients.
  • High-risk patients exhibited significantly worse overall survival.
  • The high-risk group showed increased immune cell infiltration and enriched immune pathways.
  • Differential expression of DRLs was confirmed in AML samples via qPCR.

Conclusions:

  • The identified DRL signature accurately predicts AML prognosis.
  • This signature offers insights into disulfidptosis mechanisms in AML.
  • Findings support personalized immunotherapy strategies for AML patients.