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Correlation between pan immune inflammation value and testosterone deficiency risk increase.

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The study found a positive correlation between the platelet-to-lymphocyte ratio (PIVL) and testosterone deficiency risk. Higher PIVL levels indicate an increased likelihood of experiencing testosterone deficiency.

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Area of Science:

  • Endocrinology
  • Immunology
  • Men's Health

Background:

  • Testosterone deficiency significantly impacts male health and quality of life.
  • Inflammation is linked to testosterone levels, with PIVL emerging as a novel immune-inflammatory biomarker.
  • The relationship between PIVL and serum testosterone remains largely unexplored.

Purpose of the Study:

  • To investigate the association between PIVL and serum testosterone levels.
  • To determine if PIVL can serve as a predictive biomarker for testosterone deficiency.

Main Methods:

  • Cross-sectional study analyzing data from 7389 participants in the NHANES (2011-2016).
  • Serum total testosterone measured via isotope dilution liquid chromatography-tandem mass spectrometry.
  • PIVL calculated as (neutrophil count × monocyte count × platelet count)/lymphocyte count.
  • Weighted logistic regression, smooth-fit curves, and subgroup analyses employed.

Main Results:

  • A positive correlation was observed between PIVL and the risk of testosterone deficiency.
  • Participants in the highest PIVL quartile had a 51% increased risk of testosterone deficiency compared to the lowest quartile (OR=1.51, 95% CI: 1.18-1.95).
  • A nonlinear relationship was identified with a threshold effect at PIVL of 565.89.

Conclusions:

  • PIVL is positively correlated with an increased risk of testosterone deficiency.
  • PIVL may function as a potential indicator for identifying individuals at risk of testosterone deficiency.
  • Further research is warranted to explore the clinical implications of PIVL in men's health.