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Association between periodontitis and prostate cancer: A case-control study.
Glayson P Vitor1, Ana P Carvalho1, Rafael P Esteves Lima1
1Department of Dental Clinics, Oral Pathology and Oral Surgery, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Journal of Periodontology
|April 21, 2025
Summary
Periodontitis (PE), a gum disease, is linked to a higher risk of prostate cancer (PC). Men with PE may benefit from prostate cancer screenings.
Area of Science:
- Oral health and oncology
- Chronic inflammation and disease pathogenesis
Background:
- Chronic inflammation is implicated in cancer development and progression.
- Previous studies suggest a link between periodontitis (PE) and prostate cancer (PC), but findings are inconsistent.
Purpose of the Study:
- To investigate the association between periodontitis and prostate cancer.
- To identify shared risk factors between periodontitis and prostate cancer.
Main Methods:
- A case-control study involving 152 PC cases and 220 controls.
- Participants received periodontal examinations and provided sociodemographic and medical data.
- Logistic regression analysis assessed the association between PC occurrence/severity and covariates.
Main Results:
- Higher prevalence and severity of PE were observed in PC cases (p=0.012, p=0.007).
- PC occurrence was associated with lower education, smoking, alcohol, hypertension, and PE (OR=1.80).
- PE was linked to Gleason grades 1 and 2 PC, but not higher grades.
Conclusions:
- Periodontitis is associated with the occurrence of prostate cancer.
- Screening for prostate alterations may benefit males diagnosed with periodontitis.
