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Updated: May 10, 2025
12:33
Origami Inspired Self-assembly of Patterned and Reconfigurable Particles
Published on: February 4, 2013
21.6K
Dynamic Chiral Folding for Arene-Perfluoroarene Force Driven Clamping
Yunying Xu1, Aiyou Hao1, Pengyao Xing1
1School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China.
Nano Letters
|April 21, 2025
Summary
Researchers designed intelligent peptide-based supramolecular systems that exhibit ultra-high sensitivity to solvent environments. These systems demonstrate adaptable chiroptical properties for advanced sensing and recognition applications.
Area of Science:
- Supramolecular Chemistry
- Peptide Self-Assembly
- Chiroptical Materials
Background:
- Peptide folding is crucial for designing intelligent chiral supramolecular systems.
- These systems have potential applications in sensing and recognition.
Purpose of the Study:
- To conjugate dual short peptide arms onto an aromatic core for intramolecular folding.
- To achieve efficient chirality transfer to terminal pyrenes.
- To develop a peptide-based clamp for controlling guest complexation.
Main Methods:
- Conjugation of peptide arms to an aromatic core.
- Control of aromatic core skeleton and appended luminophores.
- Analysis of chiroptical properties (circular dichroism, circularly polarized luminescence).
- Investigation of guest binding dynamics via arene-perfluoroarene interactions.
Main Results:
- Efficient chirality transfer to terminal pyrenes was achieved.
- The transferred chirality showed ultrahigh sensitivity to solvent environments.
- Specific solvent accommodation in dipeptide micropockets induced chiroptical inversion.
- A dynamic peptide-based clamp was constructed to control endo- and exo-type complexation.
Conclusions:
- Peptide folding enables the design of adaptable, chiral supramolecular systems.
- These systems exhibit sensitive chiroptical responses to external stimuli.
- The developed peptide clamp offers a novel approach for molecular recognition and material design.
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