Related Experiment Video
Updated: May 10, 2025
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
Published on: February 28, 2013
25.7K
Cardiometabolic disease management: influences from epigenetics
Natalia Atzemian1, Shafeeq Mohammed1, Ludovica Di Venanzio1
1Center for Translational and Experimental Cardiology (CTEC), Zurich University Hospital, University of Zurich, Zurich, Switzerland.
Epigenomics
|April 21, 2025
Summary
Epigenomics, the study of gene expression changes without altering DNA sequence, offers new ways to manage cardiometabolic diseases (CMD). Understanding these epigenetic changes can lead to precision medicine for reducing cardiovascular risk.
Area of Science:
- Epigenomics and its role in non-communicable diseases.
- Cardiometabolic disease (CMD) research.
- Precision medicine and therapeutic targets.
Background:
- Epigenetic modifications are key "non-genetic determinants" in disease development.
- Environmental factors (air pollution, toxins, noise) and lifestyle choices (smoking, obesity, diabetes) influence epigenetics.
- Epigenetic signatures are linked to cardiometabolic disease (CMD) manifestation.
Purpose of the Study:
- To provide an overview of recent advancements in epigenetic mechanisms in CMD.
- To explore potential therapeutic opportunities for CMD based on epigenetics.
- To highlight the role of epigenetics in inter-individual differences in CMD.
Main Methods:
- Review of current literature on epigenetics and cardiometabolic disease.
- Analysis of environmental and lifestyle factors impacting epigenetic signatures.
- Exploration of molecular targets and epi-drugs for precision medicine.
Main Results:
- Epigenetic alterations are significantly implicated in the development and progression of CMD.
- Environmental stressors and cardiovascular risk factors modulate epigenetic patterns.
- Individual epigenetic variations contribute to differential susceptibility and outcomes in CMD.
Conclusions:
- Epigenetic insights are crucial for understanding CMD pathogenesis.
- Targeting epigenetic mechanisms offers promising therapeutic strategies for CMD.
- Precision medicine approaches leveraging epigenetics can reduce cardiovascular risk in CMD patients.
Related Concept Videos
01:46Epigenetic Regulation
30.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
30.7K
01:28Human Genetics
470
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
470
02:30Genomic Imprinting and Inheritance
32.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
32.8K
01:19Overview of Carbohydrate Metabolism
535
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
535
01:20Gene-Environment Interactions
214
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
214
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K