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An Implantable In-Hydrogel Wireless Supercapacitor-Activated Neuron System Enables Bidirectional Modulation.

Xiangyu Sheng1, Zhijian Du2, Zhiyi Gao3

  • 1Hunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou, 412007, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|April 21, 2025
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Summary

This study introduces a new wireless brain stimulation system using an in-hydrogel supercapacitor. This safe, bidirectional system can modulate neural activity for treating neurological and emotional disorders.

Keywords:
cerebral neuronhydrogelin situ radical additionmultimodule supercapacitorwireless

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Cerebral neuron modulation is crucial for treating motor, emotional, and cognitive disorders.
  • Existing electrical/electrochemical stimulation methods lack security and offer only unidirectional control.
  • There is a need for safer, more effective methods for bidirectional neural modulation.

Purpose of the Study:

  • To develop an implantable, wireless supercapacitor-activated neuron system for safe and effective bidirectional neural modulation.
  • To enhance neural activity (excitation) and inhibit neural activity.
  • To explore the potential for treating neurological and emotional disorders.

Main Methods:

  • Fabrication of an implantable in-hydrogel wireless supercapacitor-activated neuron system.
  • The system comprises a coil, diode bridge circuit, in-hydrogel supercapacitor, and stimulation electrodes.
  • In situ radical addition mechanism for hydrogel encapsulation to enhance charge storage.

Main Results:

  • The in-hydrogel supercapacitor demonstrated a ≈90-fold increase in charge storage capacity compared to non-encapsulated devices.
  • The system successfully provided bidirectional and adjustable ion diffusion current for neural modulation.
  • Implantation in the thalamus, amygdala, and prefrontal lobes evoked targeted changes in neural potential intensity and frequency.

Conclusions:

  • The developed in-hydrogel wireless supercapacitor system offers a safe and effective approach for bidirectional neural modulation.
  • This technology shows significant potential for ameliorating and treating conditions such as Parkinson's disease, severe depression, and Alzheimer's disease.
  • The system's design overcomes limitations of existing neural stimulation techniques, paving the way for advanced therapeutic interventions.