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Updated: May 10, 2025

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Dilemmas in Secondary Stroke Prevention
Stephanie Vu1, Noor Mahmoud1, Shravan Sivakumar1
1Department of Neurology (S.V., N.M., S.S., M.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Abstract:
Secondary stroke prevention encompasses many approaches, including antithrombotic therapy, risk factor management, and a healthy lifestyle. Recommendations are typically based on the results of randomized clinical trials that provide evidence of benefit. However, in some situations, clinicians extrapolate the results of clinical trials into everyday practice, or trials have not provided sufficient information to make treatment decisions. This review will discuss 4 scenarios: dual-antiplatelet therapy, the perils of combining antiplatelet and anticoagulation, indications for statin therapy, and therapeutic considerations for patients with paroxysmal atrial fibrillation.
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