Mapping the therapeutic landscape of CRISPR-Cas9 for combating age-related diseases
Qiyu He1, Yida Wang2, Zhimin Tan3
1Department of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Abstract:
CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) has emerged as a transformative genome-editing tool with significant therapeutic potential for age-related diseases, including Alzheimer's disease, Parkinson's disease, cardiovascular disorders, and osteoporosis. This study presents a bibliometric analysis of CRISPR-Cas9 research in age-related diseases, identifying key contributors, major research hotspots, and critical technological advancements. While promising applications have been demonstrated in gene repair, functional regulation, and molecular interventions, significant barriers persist, including off-target effects, low delivery efficiency, and limited editing in non-dividing cells. Ethical concerns over germline editing and gaps in long-term safety data further complicate clinical translation. Future directions emphasize the development of high-precision Cas9 variants, homology-directed repair-independent tools, and efficient delivery systems, alongside the establishment of international regulatory frameworks and multicenter clinical trials. These efforts are essential to fully realize the potential of CRISPR-Cas9 in addressing the global health challenges of aging.
Insights
CRISPR-Cas9 gene editing shows promise for age-related diseases like Alzheimer's and Parkinson's. Challenges include delivery and safety, requiring further research for clinical use.
Area of Science:
- Genomics and Biotechnology
- Molecular Biology
- Aging Research
Background:
- CRISPR-Cas9 is a revolutionary genome-editing technology.
- Age-related diseases pose significant global health challenges.
- The therapeutic potential of CRISPR-Cas9 for these conditions is under investigation.
Purpose of the Study:
- To conduct a bibliometric analysis of CRISPR-Cas9 research in age-related diseases.
- To identify key researchers, research trends, and technological advancements.
- To assess the current landscape and future directions of this research area.
Main Methods:
- Bibliometric analysis of scientific literature.
- Identification of publication trends, influential works, and research clusters.
- Review of technological advancements and challenges in CRISPR-Cas9 applications.
Main Results:
- Highlighted key contributors and major research hotspots in CRISPR-Cas9 for aging diseases.
- Demonstrated promising applications in gene repair and molecular interventions.
- Identified persistent barriers such as off-target effects, delivery efficiency, and ethical concerns.
Conclusions:
- CRISPR-Cas9 holds therapeutic promise for age-related diseases but faces significant hurdles.
- Further development of precise editing tools, efficient delivery systems, and robust safety data is crucial.
- International collaboration and clinical trials are needed for successful translation.
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