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Cardiovascular responses to parathyroid hormone.

M F Crass, P L Moore, M L Strickland

The American Journal of Physiology

|August 1, 1985

Summary

Parathyroid hormone fragment (PTH-(1-34)) effectively dilates coronary arteries in dogs. This potent vasodilator increases coronary blood flow at low doses without significantly impacting blood pressure or heart rate.

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Area of Science:

Cardiovascular Pharmacology
Endocrinology

Background:

Parathyroid hormone (PTH) plays a role in calcium homeostasis.
The cardiovascular effects of PTH, particularly on coronary circulation, are not fully understood.

Purpose of the Study:

To characterize the coronary vasodilatory effects of the synthetic amino terminal fragment of parathyroid hormone, PTH-(1-34).
To investigate dose-related cardiovascular effects and the mechanism of action of PTH-(1-34) on coronary arteries.

Main Methods:

Instrumented open-chest dogs were used to study cardiovascular responses.
Intracoronary injections and infusions of PTH-(1-34) were administered.
Pharmacological blockades (adrenergic, muscarinic, histaminergic) were employed to assess the mechanism.

Main Results:

PTH-(1-34) demonstrated potent coronary artery vasodilation in a dose-dependent manner.
Low doses of PTH-(1-34) increased coronary blood flow with minimal changes in blood pressure, heart rate, or contractile force.
Higher doses led to decreased blood pressure and increased heart rate and contractile force.
The vasodilatory effect was sustained during infusion and was not affected by adrenergic, muscarinic, or histaminergic blockade.

Conclusions:

PTH-(1-34) is a potent coronary vasodilator at doses that do not cause significant systemic cardiovascular side effects.
The vasodilatory mechanism of PTH-(1-34) on coronary arteries appears to be specific and independent of major neurochemical pathways.

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