Related Experiment Video

Updated: May 10, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Pre-eclampsia Complicated by HELLP Syndrome in a Primigravida: A Case Report

Nabeelah Ismail1, Muhammad Faraaz Ismail1, Eman Ibrahim2

  • 1General Medicine, Thumbay University Hospital, Ajman, ARE.

Cureus
|April 21, 2025
PubMed

Pre-eclampsia is a hypertensive disorder of pregnancy that can rapidly progress to HELLP syndrome, increasing maternal and fetal risks. We report a case of a 33-year-old primigravida at 28+1 weeks gestation who presented with severe hypertension, proteinuria, and reduced fetal movements. Despite initial management, she developed progressive thrombocytopenia, worsening liver function, and oligohydramnios, necessitating close monitoring. Biochemical markers indicated worsening disease, prompting an emergency cesarean section at 28+6 weeks, delivering a growth-restricted neonate. Postoperatively, the patient showed gradual improvement, and histopathology confirmed placental malperfusion. This case underscores the importance of early recognition, biochemical monitoring, and timely delivery in managing severe pre-eclampsia and preventing life-threatening complications.

Keywords:
hellp syndromehypertensive disorders of pregnancyintrauterine growth restrictionplacental insufficiencypre-eclampsia

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