Non-typhoidal Salmonella Infections: Insights From a Case With Cardiac and Bone Involvement and Multisystem...

Area of Science:

• Infectious Diseases
• Cardiology
• Internal Medicine

Background:

• Non-typhoidal Salmonella (NTS) typically causes mild diarrhea but can lead to severe invasive disease in immunocompromised or vulnerable populations.
• Invasive NTS disease is challenging due to its rarity, clinical severity, and lack of established treatment guidelines.
• Vulnerable individuals may experience severe outcomes like bacteremia and multisystem involvement.

Observation:

• A 61-year-old woman with multiple comorbidities presented with a complex clinical picture.
• The patient developed infective endocarditis with subsequent septic embolization.
• Diagnostic workup revealed a renal abscess and spondylodiscitis.

Findings:

• The patient's condition progressed to endocarditis with septic embolization, a rare complication of NTS infection.
• Systemic embolization was linked to suspected valvular vegetations.
• The diagnostic evaluation identified a renal abscess and spondylodiscitis, indicating widespread infection.

Implications:

• This case underscores the potential for severe, invasive non-typhoidal Salmonella infections, even in non-endemic settings.
• Clinicians should consider invasive NTS disease in vulnerable patients presenting with severe symptoms and multiple organ involvement.
• Further research is needed to establish clear guidelines for managing invasive NTS infections, particularly complex cases involving endocarditis and systemic embolization.