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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Meningoencephalitis probably associated with dengue infection in an 84-year-old patient: A case report
1Specialist Internal Medicine at the Centro Medico El Buen Samaritano, Honduras.
Abstract:
Dengue meningoencephalitis is a rare neurological complication of dengue infection, characterized by inflammation of the brain and leptomeninges. We present the case of an 81-year-old female patient with a five-day history of fever, accompanied by altered consciousness, seizures, and meningeal signs. Dengue infection was confirmed by a positive RT-PCR result in blood, and cerebrospinal fluid analysis revealed lymphocytic pleocytosis, suggestive of a viral infectious process. Additionally, an electroencephalogram showed focal epileptiform activity. This is the first reported case of dengue meningoencephalitis in Central America. This case highlights the importance of considering dengue virus as a potential etiological agent in patients presenting with fever and acute alterations in consciousness secondary to a viral infectious process. The publication of this case is relevant to enhance early recognition of rare neurological complications such as dengue meningoencephalitis, promoting timely intervention that may positively influence patient prognosis.
Insights
Dengue meningoencephalitis, a rare brain inflammation from dengue infection, was diagnosed in an 81-year-old woman. This case underscores the need to consider dengue in fever patients with neurological symptoms.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- Dengue virus infection can rarely cause neurological complications.
- Dengue meningoencephalitis involves inflammation of the brain and meninges.
Observation:
- An 81-year-old female presented with fever, altered consciousness, seizures, and meningeal signs.
- Dengue infection confirmed via RT-PCR; CSF showed lymphocytic pleocytosis.
- EEG revealed focal epileptiform activity.
Findings:
- This is the first reported case of dengue meningoencephalitis in Central America.
- The patient's presentation included symptoms consistent with viral meningoencephalitis.
Implications:
- Highlights the importance of considering dengue virus in patients with fever and acute neurological alterations.
- Emphasizes early recognition of rare dengue-related neurological complications for timely intervention and improved prognosis.
