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ABO blood group and risk of pre-eclampsia: A case-control study
Holy Bezanahary1,2,3, Jonathan Thiolon4, François Dalmay1
1Inserm, U1094, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Limoges, France.
Background:
It appears that some ABO blood groups may be a risk factor for venous thrombosis. The association between ABO group and risk of pre-eclampsia remains controversial. The purpose of this study was to evaluate the relationship between pre-eclampsia and ABO groups.
Methods:
A retrospective case-control (1:2) study in a prospective monocentric registry including 20171 pregnancies was performed. Women with pre-eclampsia and severe pre-eclampsia were identified. Controls were matched according to age, parity, year of delivery and body mass index. Blood groups were considered.
Results:
Two hundred fifty-three cases and 506 controls were included. No difference in distribution was found between cases and controls for non-O group (57.51% vs 62.56, p: 0.19), group A (39.92% vs 44.05, p: 0.29), group B (13.83% vs 15.42, p: 0.57) group AB (3.75 vs 3.08, p: 0.64). The analysis extended to severe pre-eclampsia showed no difference.
Conclusion:
This study did not document any relationship between ABO groups and the risk of preeclampsia.
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